Rarity Redefined: Anti-Ku Antibody–Associated Myopathy In a Child
DOI:
https://doi.org/10.69980/vrhs1f47Keywords:
Anti-Ku antibody, Inflammatory myopathy, pediatric myositis, autoimmune myopathy, rare caseAbstract
Background
Anti-Ku antibody–associated inflammatory myopathy is a rare autoimmune disorder, predominantly described in adults and only rarely reported in pediatric patients.
Case-Presentation
An 8-year-old male presented with a one-month history of high-grade fever followed by progressive proximal muscle weakness, leading to difficulty in walking and performing overhead activities. There was no history of rash, joint symptoms, or trauma. Examination revealed symmetric proximal muscle weakness.
Management & Outcome
Laboratory evaluation showed markedly elevated muscle enzymes (CK, AST, LDH) and inflammatory markers. Autoimmune workup revealed positivity for anti-Ku antibodies. MRI of lower limbs demonstrated T2/STIR hyperintensities suggestive of inflammatory myopathy. The patient was treated with pulse methylprednisolone followed by oral corticosteroids and methotrexate, resulting in significant clinical improvement and restoration of functional mobility.
Conclusion
This case highlights a rare early presentation of anti-Ku myopathy in childhood. Early recognition using serological and radiological correlation and prompt immunosuppressive therapy can significantly improve outcomes.
